It becomes more than essential for a clinical pharmacologist to understand the various principles and modes of drug administration, since these are clinically relevant in therapeutics, and helps in avoiding any potential harm to patients receiving these drugs. While there are several principles of drug administration, the five important ones are: the right patient, the right drug, the right dose, the right time and the right route of administration. Modes or routes of drug administration vary from the widely followed oral route to parenteral and inhalational routes. There also exist certain specialized routes and modes of drug delivery, like the liposomal delivery, prodrug delivery and others. Each of these routes of administration has its own pros and cons, which have to be weighed against each other before choosing the same. This chapter deals about the key principles and routes or modes of drug administration. Show
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Rights and permissionsReprints and Permissions Copyright information© 2019 Springer Nature Singapore Pte Ltd. About this chapterCite this chapterArivazhahan, A. (2019). Principles and Modes of Drug Administration. In: Raj, G., Raveendran, R. (eds) Introduction to Basics of Pharmacology and Toxicology. Springer, Singapore. https://doi.org/10.1007/978-981-32-9779-1_4 What route of administration is commonly used for emergency drugs?Rate and extent of absorption from the drug administration site: Drugs used in emergencies are usually given intravenously for quick effect. Effect of digestive juices and first pass metabolism: For example, since nitroglycerine is digested to a large extent when taken orally, it is given by alternate routes.
Which method of drug administration is only used during emergency resuscitation?Conclusions: IO administration is a safe and effective method for delivering drugs during cardiopulmonary resuscitation. It should be considered whenever intravenous access cannot be rapidly obtained.
What is the preferred method of drug administration?Intravenous administration is the best way to deliver a precise dose quickly and in a well-controlled manner throughout the body. It is also used for irritating solutions, which would cause pain and damage tissues if given by subcutaneous or intramuscular injection.
What are the 3 main routes of drug administration?Action may be topical (local), enteral (system-wide effect, but delivered through the gastrointestinal tract), or parenteral (systemic action, but delivered by routes other than the GI tract). Route of administration and dosage form are aspects of drug delivery.
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